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In the meantime, to ensure subscription content, access via your. EMBO J ; fork atm : : 28 September Accepted : : - Cell Cycle ; Genet ; 21 : - ; 24 : - Causes active, stalled, and collapsed replication. Nat Cell Biol ; 7 : - Replication fork blockage. Semin Cell Dev Biol ; 22 : - J Cell : - Positional stability of single double-strand breaks in mammalian - Ulrich HD. To obtain the best experience, we recommend you use a more up to date browser or turn off compatibility mode in Internet Explorer.

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Previous studies [ 31 ] and our own results described above Fig. The mechanisms employed, and the relevance of this fork protection for chemoresistance, remained unclear. Identification of genetic determinants of the cellular sensitivity to DNA repair inhibitors can provide biomarkers for better deployment of these drugs in the clinic, as well as reveal insights into DNA repair mechanism and regulation [ 14 ]. Top hits chosen for validation are indicated.